Part 2 Immunology(50-99) prof. Keit Vanseth

50. The major role of the complement C3b is to work in conjunction with:

 Antibodies to lyse cells antgen

 MHC for cell recognition

 Antibodies to opsonize cells

 T-cell for production of lymphokines

51. All of the following are true for IgE molecules, EXCEPT:

 They involved in allergic reactions.

 They anti-parasitic immune responses.

 They can fix complement.

 They can cause the release of histamine.

52. Which of the following immunoglobulin can across placenta with the highest concentration?:

 IgG1

 IgG2

 IgG3

 IgG4

53. All of the following are true about antibodies, EXCEPT:

 They fix complement.

 They occur on the surface of B-lymphocyte

 They are glycoproteins.

 They are polypeptide

54. In the complement system, the lytic pathway initiated by the complement :

 C1qrs

 MBL

 C4

 C5

55. All of the following are true, EXCEPT:

 An epitope is a portion of an antigen

 The variable contain the antigen recognition site

 IgM antibody is pentamer

 IgG antibody is pentavalent

56. Which immunoglobulin is the principal one that is unkown function:

 IgG

 IgM

 IgA

 IgD

57. Individuals make up over C4a would be expected to have:

 Diabetis

 Anaphylaxia

 Liver disease

 Bacteria

58. The immunoglobulin class which is the second abundant in the normal adult is:

 IgG

 IgA

 IgD

 IgE.

59. In the alternative pathway of the complement system, the factors below are useful to stabilise the generation of C3 convertase :

 Factor P

 Factor F

 C3-BP

 C1-INH

60. The factor that dissociated the initiation of C1qrs in the classical pathway is:

 C3-BP

 Factor F

 Factor P

 C1-INH

61. The type of an immunoglobulin is determined by:

 The variable region

 The light chain

 The heavy chain

 The carbohydrate

62. Each of the following is a characteristic of antibodies, EXCEPT :

 They are proteins with variable and constant regions

 They contain carbohydrates

 They are only secreted by T-cells

 They combine specifically with antigen

63. The T3 complex of the T-cell receptor:

 To transduce a signal to the cell's interior

 Binds complement

 Causes the histamine

 Mediates Immunoglobulin class switching

64. Which of the following is NOT true of interleukins?:

 Produced by cells of the immune system.

 Relation between cells of immune system

 They have receptors on the target cell.

 They bind antigen with a high specificity.

65. The following statements are true for IgE, EXCEPT:

 They produce allergic reaction

 The least immunoglobulin in the plasma

 They bind to mast cells

 Can cross the placental barrier

67. The following statements are true, EXCEPT:

 IgM and IgG can fix complement

 IgA is a secretory immunoglobulin

 IgE mediates hypersensitivity

 IgD provides passive immunity

68. The following statements are true for Antibodies, EXCEPT:

 Non immunogen

 Composed of variable and constant regions

 Made of heavy and light chains

 They have hypervariable region

69. The following statements are not true for Immunoglobins

 They have Fab

 Five major classes of immunoglobulin

 All have receptors for complement

 Possess both variable and constant regions

70. The following statements are true for Antibodies

 Are carbohydrates

 Are made from alpha and beta chains

 Contain cytoplasmic region

 Have variable region

71. The Biological Effects of C3b is :

 Susceptibility to bacterial infections

 Anaphylaxia

 Phagocyte activation

 Lack of opsonisation

72. The following statement is for MHC Class I:

 Recognized by the CD8 protein

 Used to kill by cytotoxic T-cells

 Participated in helper function

 Not able to carry an antigen fragment

73. The major histocompatibility complex proteins function to:

 Degrade T4 and T8 polypeptides

 Bind antibody for lymphokine production

 Bind complement for cell lysis

 Bind antigen for presentation to T-cells

74. Variable domains are:

 Needed to bind complement

 Located at the N-terminal of heavy chains

 Transported IgG across the placenta

 Specific recognition of antigen

75. The light chains of antibodies are distinguished by:

 Their constant specific region

 Their variable region domains

 Kappa or lambda types

 The J-chains that bind to them

76. Which of these cell types can play a primary role in attacking and killing cancer cells?:

 Platelet

 Cytotoxic

 T cell

77. The J-chain is :

 Made only by epithelial cells

 For immunoglobulin multimer formation

 For immunoglobulin multimer formation and Facilitates secretion of pentameric lgM

 Facilitates secretion of pentameric lgM

78. The functional activity of the T-cell:

 Is related with CD4 or CD8 associated polypeptides

 Occurs after recognition of an epitope

 Can be mediated through cytokines

 All answers

79. The followings statement are FALSE for Target cell lysis and destruction :

 Tc recognizing specific epitopes

 Perforin released from Tc

 C3b fix to IgG and IgM which have epitopes

 C3b fix to IgE which have epitopes

80. The followings statement are TRUE, EXCEPT:

 MHC I bind antigen and recognized by the Tc

 MHC I presented on all cells of the immune

 MHC II bind antigen and recognized by the Th

 MHC II carrying antigen presented to Tc

81. What distinguishes helper T-cells from cytotoxic T-cells:

 Th recognize antigen with MHC I

 Tc recognize antigen with MHC I

 Th recognize antigen with MHC II

 Tc recognize antigen with MHC I and Th recognize antigen with MHC II

82. Clinical abnormalities of the Immune system can result from the following statement, EXCEPT:

 Deficiency diseases

 Abnormal lymphocyte proliferation

 HIV Infection

 T cells proliferation

83. Which of the following represent immune system dysfunctions:

 Severe immunodeficiency

 Mast cells release histamine

 Facilitated by antibodies

 T cells proliferation

84. The following statement are for adaptive immune response, EXCEPT :

 Is mediated by the humoral and cellular of the immune

 Can be facilitated by antibodies

 Can be facilitated through T-cells

 Can be facilitated through macrophage cells

85. Which of the followings are NOT TRUE regarding an immune response:

 The principal function of the T3 complex is signal transduction to the cell's interior

 The T8 serves an auxiliary role with MHC class I proteins in cytotoxic reactions

 The T4 serves an auxiliary role with MHC class II proteins in helper cell reactions

 Lymphokines are produced by T-cells in response to antigen presentation by antibody

86. Skin is a________ barrier:

 Anatomical

 Physiological

 Phagocytic

 Inflammatory

87. Which among the following is anti-bacterial ?:

 Interferon

 Lysozyme

 Hormone

 Protein

88. Which of the following is antiviral:

 Lysozyme

 Interferon

 Protein

 Hormone

89. Histamine is secreted by:

 Epithelial cell

 Mast cells

 Red blood cells

 White blood cells

90. Humoral immunity consists of:

 Normal cells

 Pathological cells

 Cytotoxic cells

 Immunoglobulins

91. Complement deficiencies of C3b can cause:

 Overproduction of C2b

 Glucose oxidase deficiency

 Predisposition to SLE

 Bacterial infection

92. Which of the following causes AIDS ?:

 Bacteria

 Fungus

 Retrovirus

 TMV

94. Complements are chemically:

 Glycogens

 Glycoproteins

 Lipoproteins

 Proteins

95. Hyper variability regions are present in:

 Heavy chain only

 Light chain only

 Heavy and light

 Dark chain

96. Organ transplantation of human from one place to another is called:

 Autograft

 Allo-graft

 ISO-graft

 Xeno-graft

97. Graft between identical twins is called:

 Xeno-graft

 Allograft

 Auto graft

 Iso graft

98. What is the term used to describe white blood cells migrating toward bacteria? :

 Zeiosis

 Phagocytosis

 Chemotaxis

 Phototaxis

99. Name the process a cell such as a neutrophil or a macrophage uses to ingest (eat) its prey.:

 Halitosis

 Chemotaxis

 Botulism

 Phagocytosis